KOL Call on LUMEVOQ® for the Treatment of Leber Hereditary Optic Neuropathy (LHON)

The call will feature presentations by Key Opinion Leaders (KOLs) Nancy Newman, MD (Emory Eye Center) and Sean Donahue, MD, PhD (Vanderbilt Children’s Hospital) who will discuss the current treatment landscape and unmet medical needs in Leber Hereditary Optic Neuropathy (LHON). Drs. Newman and Donahue will be available to answer questions at the conclusion of the call.

Additionally, GenSight’s management team will give an update on the company and discuss the results from the REVERSE and RESCUE Phase III trials for LUMEVOQ^® (GS010). RESCUE and REVERSE are two separate randomized, double-masked, sham-controlled Phase III trials designed to evaluate the efficacy of a single intravitreal injection of GS010 (rAAV2/2-ND4) in subjects affected by LHON due to the G11778A mutation in the mitochondrial ND4 gene. LUMEVOQ^® (GS010) is expected to be submitted for European approval in September 2020.

LUMEVOQ^® (GS010) targets Leber Hereditary Optic Neuropathy (LHON) by leveraging a proprietary mitochondrial targeting sequence (MTS) technology platform developed from research conducted at the Institut de la Vision in Paris. The technology enables GS010 to use an engineered AAV (Adeno-Associated Virus) vector to address defects inside the mitochondria.

Dial-In & Webcast Information

• Domestic: 1-877-705-6003
• International: 1-201-493-6725
• Conference ID: 13705257

Enter Webcast:  click here

For those who are unable to listen at this time, a replay of the call will be available by clicking here.

Q&A Information 

If you would like to ask a question during the live Q&A, please submit your request via email : Email Q&A

KOL Biographies

• Nancy Newman, MD

Nancy J. Newman, MD is the LeoDelle Jolley Professor of Ophthalmology, Professor of Ophthalmology and Neurology and Instructor in Neurological Surgery at the Emory University School of Medicine, where she serves as the Director of Neuro-Ophthalmology. She attended Princeton University, the University of London on a Marshall Scholarship, and Harvard Medical School. She trained in Internal Medicine and Neurology at the Massachusetts General Hospital where she was Chief Resident in Neurology, and in Neuro-Ophthalmology at the Massachusetts Eye and Ear Infirmary. She is a Fellow of the American Academy of Neurology, the American Neurological Association, and the North American Neuro-Ophthalmology Society.

She was President of the North American Neuro-Ophthalmology Society from 2014 to 2016, Chair of the Board of Directors from 2016 to 2018, and is now Senior Vice President for Education. She has served on the Editorial Boards of the American Journal of Ophthalmology, Seminars in Neurology, Journal of the Neurological Sciences and the Journal of Neuro-Ophthalmology. She has over 500 publications, including scientific articles, book chapters and books, including the primary textbook in Neuro-Ophthalmology, Walsh & Hoyt’s Clinical Neuro-Ophthalmology, 5^th and 6^th Editions, and the popular manual Neuro-Ophthalmology Illustrated, 1^st, 2^nd and 3^rd Editions. She has lectured widely throughout the world and is known for her innovative teaching style. Her main research interests include disorders of the optic nerve and mitochondrial diseases. She is a Trustee Emerita of the Board of Trustees of Princeton University and also served as President of the Princeton University Alumni Association.

• Sean Donahue, MD, PhD

Sean P. Donahue, MD, PhD is currently the Vice Chair for Clinical Affairs in the Department of Ophthalmology and Visual Sciences at Vanderbilt University Medical Center in Nashville, TN. He attended College at the University of Dayton, followed by Medical and Graduate training at Emory University. Dr. Donahue was fellowship trained in Pediatric Ophthalmology and Neuro-ophthalmology at the University of Iowa after completing his residency in Ophthalmology at the University of Pittsburgh.  His primary clinical interests are in the diagnosis and management of pediatric ophthalmological problems, and in the surgical management of complicated strabismus syndromes.  He is a member of the American Association for Pediatric Ophthalmology and Strabismus, the American Academy of Ophthalmology, the Heed Society, the Association for Research in Strabismus (Squint Club), and the American Ophthalmological Association (AOS). He holds the inaugural Sam and Darthea Coleman Chair in Ophthalmology at Vanderbilt.

Dr. Donahue has served as the Program Chair for the American Association for Pediatric Ophthalmology and Strabismus, and on the Program Committee for the annual meetings of the North American Neuro Ophthalmology Society (NANOS) and the AOS.  He has been on the Executive Committee, the Strabismus Steering Committee, and the Pediatric Optic Neuritis Study Planning Committee for the Pediatric Eye Disease Research Group. He recently served as the Protocol Chair for the Intermittent Exotropia Surgery Study, which was the first NEI-sponsored multi-centered surgical study in pediatric ophthalmology in over 30 years.  He is an Executive Editor of the American Journal of Ophthalmology, and has been on the editorial boards of the Journal of AAPOS, and the Journal of Clinical Neuro ophthalmology. He has published over 300 peer-reviewed manuscripts, book chapters, and editorials, with over 100 as first author.  He is widely sought-after as a guest lecturer and has spoken about clinical issues in pediatric ophthalmology on all six populated continents. He is the past winner of the NANOS Young Investigator Award (2000), a Research to Prevent Blindness Career Development Award, and the Lifetime and Senior Achievement awards from AAO and AAPOS. He was awarded the Distinguished Alumnus Award from the University of Dayton in 2015.